MOTS-c for Sale
Mitochondrial peptide for energy and metabolism research.
$59.99 30% off
MOTS-c is a mitochondrial-derived peptide that signals to the nucleus and is studied for its role in metabolic balance, cellular energy and exercise physiology. It sits at the intersection of the metabolism and longevity research categories.
Buy MOTS-c online from Healio. MOTS-c for sale comes as a 10mg vial, supplied as a research peptide for laboratory use only and shipped from the USA with the batch certificate of analysis published before you order.
What is MOTS-c?
MOTS-c is a mitochondrial-derived peptide, and that phrase is doing more work than it appears to. Nearly every peptide in the body is encoded by nuclear DNA. MOTS-c is encoded in mitochondrial DNA, a remnant of the fact that mitochondria were once independent organisms with their own genome.
That makes it a signal originating inside the mitochondria and acting outward on the rest of the cell, which is an unusual direction of traffic in cellular signalling and the reason the compound attracted attention.
MOTS-c research applications
Published research covers metabolic regulation, insulin sensitivity, and the cellular response to metabolic stress. Levels appear to decline with age, following a pattern seen with several compounds studied in longevity contexts.
Because the mechanism sits at the intersection of metabolism and cellular energy production, MOTS-c appears in both metabolic research and mitochondrial ageing research rather than belonging cleanly to either.
How MOTS-c works
Research describes MOTS-c influencing metabolic pathways including AMPK signalling, a central regulator of cellular energy balance that responds to the ratio of available energy in the cell. It has also been studied in relation to nuclear gene expression, which is what makes the mitochondria-to-nucleus signalling direction interesting.
The literature is early. It is also mechanistically distinct enough that dismissing it would be as much of a mistake as overselling it.
MOTS-c vs SS-31
| Property | MOTS-c | SS-31 |
|---|---|---|
| Type | Mitochondrial-derived peptide | Synthetic targeted peptide |
| Mechanism studied | Metabolic signalling, AMPK | Cardiolipin, inner membrane |
| Research maturity | Early, growing | Formal clinical programmes |
| Primary focus | Metabolic regulation | Mitochondrial efficiency |
Both compounds appear in the best peptides for energy.
MOTS-c reconstitution and handling
Supplied lyophilized. Reconstitute with bacteriostatic water, adding diluent slowly against the vial wall and allowing the powder to dissolve undisturbed. Bacteriostatic water is stocked separately. The MOTS-c calculator turns vial strength and water volume into a concentration.
MOTS-c storage and stability
Store sealed lyophilized vials at minus 20 degrees Celsius, away from light. Reconstituted solution needs refrigeration and has a shorter usable window. Avoid repeated freeze and thaw cycles.
MOTS-c price
MOTS-c 10mg is $59.99 per vial, which works out to $6.00 per mg. Ordering more than one vial lowers the price of every vial in the order. The table shows the MOTS-c price per vial and per mg for every size. That MOTS-c cost is the price per vial before shipping. For the best price per vial on MOTS-c, order three or more.
| Size | Vials in order | Price per vial | Price per mg |
|---|---|---|---|
| MOTS-c 10mg | 1 vial | $59.99 | $6.00 |
| 2 vials 5% off | $56.99 | $5.70 | |
| 3 or more vials 10% off | $53.99 | $5.40 |
Prices are in US dollars. The multi-vial discount is applied automatically in the cart. Shipping is free on orders over $185.
Where to buy MOTS-c in the US
If you are comparing a MOTS-c vendor, start with the paperwork. The best place to buy MOTS-c is one where MOTS-c comes with a lab report you can read before you pay. Five checks separate a reliable US source from a reseller, and this is how Healio meets each one.
- A certificate of analysis for the exact batch. The MOTS-c report for batch HEALIO-MOTSC-2603 is published before you order, not emailed after you have paid.
- Testing by a lab that is not the seller. The report comes from Quantum Life Sciences in Portland, Maine, an independent laboratory, and carries its own certificate number.
- Identity as well as purity. HPLC measures how pure the powder is. Mass spectrometry (ESI-MS) confirms that it is MOTS-c in the first place. A report with only one of the two is half a report.
- A lot number you can trace. The lot number on your vial ties to its own report, so you can check the document against the product in your hands.
- US dispatch and plain terms. Orders ship from the United States, and the shipping and returns policy is public before you buy.
For a longer look at judging any supplier, read the best peptide companies.
MOTS-c lab results
The current MOTS-c batch was tested on 23 June 2026 by Quantum Life Sciences. The certificate covers the 10 mg vial. Purity is measured by HPLC and identity is confirmed by mass spectrometry. The summary below is taken from the certificate of analysis. Reading the MOTS-c COA takes a minute: purity by HPLC, identity by mass spectrometry and endotoxins are in the first rows.
| Batch | HEALIO-MOTSC-2603 |
|---|---|
| Lot number | MOTSC-260619-03 |
| Purity (HPLC) | 99.2% (specification 98.0% or higher) |
| Identity (ESI-MS) | Confirmed, conforms to the reference standard (2174.59) |
| Mass found | 10.09 mg (labeled 10 mg) |
| Endotoxins (LAL) | Under 0.5 EU/mg (limit 5 EU/mg) |
MOTS-c reviews: is Healio a legit MOTS-c source?
Reading MOTS-c reviews and complaints, or asking whether a MOTS-c brand is legit? The useful evidence is what you can check yourself, because reviews only help if you can check them.
- Match the lot number on your vial to the MOTS-c certificate of analysis.
- Look up the testing laboratory named on the certificate and confirm it is not Healio.
- Read how the content on this site is written and checked on the editorial standards page.
- If a seller will not publish a batch report for the product you are buying, treat that as your answer.
MOTS-c payment and shipping
Orders ship from the United States to US addresses. Weekday orders placed before 2:00 PM ET usually go out the same business day, and later orders go the next business day. Transit is usually 2 to 10 business days, which is a carrier estimate and not a guarantee. Pay by credit or debit card at checkout.
| Shipping option | Price |
|---|---|
| Standard Shipping (Ground) | $14.99 (free over $185) |
| 2-Day Air | $23.99 |
| Next Day Air | $54.99 |
All sales are final. Read the full shipping and returns policy before you order.
MOTS-c research tools and guides
- MOTS-c calculatorTurn vial strength and water volume into concentration and syringe units. Arithmetic only.
- MOTS-c certificate of analysisThe full lab report for the current batch.
- MOTS-c research benefitsWhat the published research looks at.
- Longevity peptidesWhere MOTS-c fits.
- SS-31 for saleThe other mitochondrial peptide.
- Epitalon for saleStudied in longevity research.
- MOTS-c vs SS-31A mitochondrial signal against a membrane protector.
Research focus
- Cellular energy research
- Metabolic balance studies
- Mitochondrial function models
- Healthy-aging research
Who it’s for
For researchers focused on
| Scientific name | MOTS-c |
|---|---|
| CAS number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.6 g/mol |
| Sequence | MRWQEMGYIFYPRKLR |
| Purity | 99%+ (HPLC) |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
Store the lyophilized powder at -20°C, protected from light. Brief exposure to room temperature during shipping does not affect stability.
After reconstitution, keep refrigerated at 2 to 8°C and use within the research window. Do not freeze the reconstituted solution.
For laboratory research use only. Reconstitute with bacteriostatic water and handle with appropriate protective equipment.
Working out the water volume? Use the MOTS-c calculator.
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MOTS-c FAQ
Where can I buy MOTS-c in the US?
Healio sells MOTS-c direct from the United States, with the batch certificate of analysis published before you order. It is supplied for laboratory research use only.
How much does MOTS-c cost?
A 10mg vial of MOTS-c is $59.99, about $6.00 per mg. Ordering two vials brings each to $56.99 and three or more brings each to $53.99. Shipping is free on orders over $185.
Is Healio MOTS-c third-party tested?
Yes. Each batch is tested by an independent US laboratory for purity by HPLC and for identity by mass spectrometry. The current batch measured 99.2% purity with identity confirmed, and the full report is on the MOTS-c COA page.
How fast does MOTS-c ship?
Weekday orders placed before 2:00 PM ET usually ship the same business day. Standard ground is $14.99 and free over $185, 2-Day Air is $23.99 and Next Day Air is $54.99. Delivery times are carrier estimates and are not guaranteed.
What payment methods does Healio accept?
Credit and debit cards, paid at checkout.
How do I reconstitute MOTS-c?
Lyophilized MOTS-c is reconstituted with bacteriostatic water. The MOTS-c calculator converts vial strength and water volume into concentration and syringe units. It is arithmetic only and does not recommend an amount.
Is MOTS-c for human use?
No. Healio supplies MOTS-c strictly for laboratory research. It is not for human or veterinary use, and it is not a drug, supplement, food or cosmetic.
What is MOTS-c used for in research?
Metabolic regulation, insulin sensitivity and mitochondrial signalling research. Supplied as a laboratory research material only.
Why is MOTS-c called a mitochondrial-derived peptide?
Because it is encoded in mitochondrial DNA rather than nuclear DNA, which is unusual and means it signals outward from the mitochondria to the rest of the cell.
How does MOTS-c compare to SS-31?
Both concern mitochondria but through different mechanisms. MOTS-c is studied for metabolic signalling; SS-31 targets cardiolipin in the inner mitochondrial membrane and has the more formal clinical development history.
